SUMMARY: mRNA COVID vaccines, previously not used outside of small laboratory animal studies, were given to billions of people after perfunctory and rushed clinical trials. As scientists learned in 2022, mRNA vaccines cause a ‘class switch’ to IgG4 antibodies. Another study found that this specific antibody subclass is associated with more aggressive cancer growth and causes hyperprogressive cancer disease in mice and humans.
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A while ago, this blog explored a unique, rare class of antibodies called IgG4, caused by repeat injections of mRNA COVID vaccines.
These IgG4 antibodies are usually created in response to persistent irritants such as worms. Unfortunately, repeat injections of mRNA Covid vaccine are perceived by our immune systems as a “persistent irritant” and cause the IgG4 antibody switch.
The “persistent irritation” effect possibly occurs not only because of repeat injections but also due to mRNA gene expression never stopping in half of the vaccinated people.
Are these IgG4 antibodies harmless? Do they have any effects outside of our immune reactions to COVID-19? Is there something to worry about?
Unfortunately, a 2020 study published in the British Medical Journal’s Journal for Immunotherapy of Cancer suggests that having more IgG4 antibodies — of ANY kind – enhances cancer progression. The study by Wang et al. was done two years before the discovery of mRNA vaccine-related class switch to IgG4 antibodies.
The study authors found cancer-enhancing effects of any IgG4 antibodies in people and laboratory mice.
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RESULTS: In a cohort of patients with esophageal cancer we found that IgG4-containing B lymphocytes and IgG4 concentration were significantly increased in cancer tissue and IgG4 concentrations increased in serum of patients with cancer. Both were positively related to increased cancer malignancy and poor prognoses, that is, more IgG4 appeared to associate with more aggressive cancer growth. We further found that IgG4, regardless of its antigen specificity, inhibited the classic immune reactions of antibody-dependent cell-mediated cytotoxicity, antibody-dependent cellular phagocytosis and complement-dependent cytotoxicity against cancer cells in vitro, and these effects were obtained through its Fc fragment reacting to the Fc fragments of cancer-specific IgG1 that has been bound to cancer antigens. … We found that local application of IgG4 significantly accelerated growth of inoculated breast and colorectal cancers and carcinogen-induced skin papilloma. We also tested the antibody drug for cancer immunotherapy nivolumab, which was IgG4 in nature with a stabilizing S228P mutation, and found that it significantly promoted cancer growth in mice. This may provide an explanation to the newly appeared hyperprogressive disease sometimes associated with cancer immunotherapy.
The scientists provide an excellent explanation of the IgG4 antibody subclass:
IgG4 is a unique antibody that has the lowest concentration among IgG subtypes in healthy individuals, and its function has not been well understood. IgG4 was regarded as a ‘blocking antibody’ because of its reduced ability to trigger effector immune reactions. Therefore whatever molecules IgG4 reacts to, the subsequent immune reaction was subdued.
The study details Wang et al.’s multidimensional investigation of IgG4 in a wide array of patients with cancer and tissues with both in vitro and in vivo experiments. Again, this research was done in 2020, well before the effects of Covid vaccines on IgG4 could be seen.
