In recent weeks readers of my online health reports have been alerted of an upcoming advancement in human health that can now be revealed — a compelling and unexpected development that is surely to alter the course of human civilization from this point forward, producing a lifespan and healthspan beyond anything ever imagined for those who opt to use it.
This is not some snake oil elixir being peddled to gullible consumers. It originates from credible peer reviewed science published in distinguished scientific journals and has both animal and human data to substantiate it, more evidence than widely touted calorie restricted diets and their molecular mimics like resveratrol that are posed to double human healthspan and lifespan.
If fully implemented it would have economic and political ramifications that would reverberate around the globe, the discovery that humans are only living a lifespan that is one-third of what they were biologically designed to live. This goal of living as long as the Biblical patriarchs can be achieved by the masses very economically. It is not an expensive technology only within reach of the wealthy.
The greatest discovery
By Matthias Rath - Why...
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Looking back, what would be the greatest discovery in the history of medicine to date? Most certainly William Fleming’s penicillin discovery in 1928 that mold destroyed bacteria in a lab dish would rank high. The countless lives that have been saved from premature death by antibiotics only serve to place this achievement at the top of the list.
Most certainly vaccines would be listed in the archives of medicine as another major discovery that is ongoing, sparing malnourished young children from childhood infectious diseases that can be killers. (However, adequate nutrition, particularly zinc, would obviate the need for vaccines altogether, a fact documented by this health writer and ignored by public health authorities.[1])
But arguably the greatest discovery now to be revealed would almost eliminate the need for #1 and #2 on the list. That would be restoration of the mutated GULO gene that many generations ago in human history halted the ability of the human body to internally produce vitamin C as most other animals do. Most mammals, except guinea pigs, fruit bats and primate monkeys, produce vitamin C internally. It is known that vitamin C-synthesizing animals don’t get heart attacks.[2]
In 1972 biochemist Irwin Stone wrote this defective gene “has been a severe handicap and the side effects of this defective gene have resulted in the deaths of more individuals, caused more sickness and suffering and have changed the course of history more than any other single factor.”[3]
The GULO gene, located in the liver, facilitates the production of the last of four enzymes (gulonolactone oxidase) that convert blood sugar into a sugar-like molecule called ascorbate (aka vitamin C).
This endogenous antioxidant was once produced upon demand in the liver. It was a stress hormone. The more mental or physical stress, the more sugar stores are released into the blood circulation to pass through the liver to be enzymatically converted to ascorbate (vitamin C).
However, a mutation in the GULO gene now renders humans totally dependent upon dietary sources of vitamin C to avoid symptoms of scurvy and death. The ability of humans to handle biological stress is limited because of this mutation.
Do some modern humans internally produce vitamin C?
Upon examination we find modern medicine has shunned and ignored evidence it didn’t care to know about – that some humans actually produce vitamin C endogenously.
In 1956 researchers were perplexed by the absence of symptoms of scurvy among the Bantu tribe children in South Africa despite very low vitamin C intake levels (3-8 milligrams/day). Investigators concluded: “the only alternative is to postulate an endogenous production of the vitamin.”[4] This finding was also ignored for decades.
Guinea pigs suffer the same genetic fate as humans, having a mutated GULO gene that blocks internal synthesis of vitamin C. But in 1971 researchers found some guinea pigs that continued to secrete vitamin C.[5]
Dr. Muge Cummings, writing in the American Journal of Clinical Nutrition in 1981, noted a female subject demonstrated high blood levels of vitamin C with progressively smaller intake. Another woman went 149 days without any vitamin C from dietary sources and never showed any symptoms.[6]
But it was as if the medical/research community really didn’t want to know. Modern medicine was making a killing off of treating all the symptoms of vitamin C deficiency to even want to pay attention. Preventing overt symptoms of scurvy (bleeding gums, painful joints, lassitude, anemia, easy skin bruising) with a few milligrams of vitamin C was good enough.
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Lame and few efforts to correct this gene mutation
Only a few attempts have been made to remedy this widespread gene mutation.
In 1996 researchers in Japan reported on the successful microinjection of fertilized fish eggs with the gulonolactone oxidase (GULO) gene, which produced an offspring that possessed GULO enzyme activity.[7]
In vitro injection of human eggs with the GULO gene may be variably successful, though there is no impetus to do this and it would only slowly convert the next generation – offspring of GULO-positive mothers — to endogenously produce vitamin C.
More recently a new gene editing technology has been proposed. It is called CRISPR (“clustered regularly interspaced short palindromic repeats.”).
Specific nucleotide sequences intended for re-insertion of the GULO gene have been described by CRISPR technologists.[8] (Genscript) So this idea is on the drawing board.
CRISPR inserts a new gene. But just knowing the DNA sequences is not the whole story. Researchers write: “There is another layer of complexity added by a group of molecules called epigenetic regulators.”[9]
Overlooked in news headlines is that there is also a modifiable dynamic aspect of genes called epigenetics characterized by protein making.
Genes that produce proteins are said to be “expressed” (switched on), and those that don’t are said to be “silenced” (switched off). Environmental factors such as temperature, radiation and food can provoke an epigenetic response. Researchers now concede CRISPR has reached a dead end. Epigenetic (protein making) mechanisms prevail that are not addressed by CRISPR.
Epigenetics already demonstrated
Epigenetics has already been demonstrated to correct an inherited single-gene mutation called beta thalassemia – an inherited deficiency of hemoglobin that requires frequent blood transfusions.
In an animal study, a modest dose of resveratrol (2.4 mg/kilogram of body weight equivalent to 168 milligrams in a 70-kilogram/150-lb human) increased red blood cell production and hemoglobin levels.[10]
Resveratrol was actually put to the test in humans and produced a complete response in 52.2% of thalassemia patients, a partial response in 18.2% and null response in 15.9% of subjects. Other patients became less dependent upon blood transfusions.[11]
Thalassemia has been selected for CRISPR gene insertion in what has been called the “world’s first gene edited humans.” A small natural molecule, resveratrol, beat CRISPR to the punch. Epigenetics prevails over genetics. You didn’t hear about this from the news media, did you?
Legendary biochemist Irwin Stone said this in 1979:
Vitamin C: The Real St...
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“This genetic approach, in which the gene is repaired or replaced so it will be capable of directing the synthesis of the active enzyme (gulonolactone oxidase)… would be a convenient solution to the problem, but the present ‘state of the art’ in genetic engineering is not capable of doing this. Perhaps another 50 years will see this accomplished. Humans would then be able to perform the endogenous synthesis of ascorbate, just like the other mammals.”[12]
The discovery
Here is the lightning bolt – – – an olive fruit extract has unexpectedly been found to double circulating blood levels of vitamin C without vitamin supplementation or an increase in dietary vitamin C intake. (Source: Redox Biology, Vol. 11, 2017)
The proposed epigenetic mechanism for this breakthrough is described elsewhere online. A dietary supplement has been formulated (Formula-216™) to raise blood levels of vitamin C without reliance upon dietary or supplemental sources of this vitamin.
Simpler way
There is an another available method of restoring vitamin C blood levels to that of vitamin C-secreting humans prior to the infamous gene mutation.
In a recent animal study[13] it was determined that laboratory mice that internally produce vitamin C lived 23.8 months on average (30 months maximum lifespan). Their blood level of vitamin C was 60-micromole per blood sample. Mice whose GULO gene was intentionally mutated for experimental purposes, mimicking the human situation, lived only 8.5 months on average (16 months maximum). Their blood level was 11.0.[14]
This is a telling experiment because it strikingly says, if this experiment can be extrapolated to humans, that humans are living only a third as long as intended (8.5 months/23.8 months).
Then a third group of laboratory mice had their GULO gene inactivated but their diet was fortified with vitamin C to achieve the same blood concentration as natural C-secreting mice (60 micromole). These animals lived 23.0 months on average (32 months maximum). In other words, vitamin C supplementation made up for this gene mutation and increased lifespan by two-thirds (2.7 times to be exact).
Modern humans live 60-80 years and if those numbers are multiplied by 2.7, you come up with the prospect of humans living 162 to 216 years! (See chart below)
A special dietary supplement has been fashioned (Formula-216™) which this health writer has formulated to raise vitamin C blood levels without reliance upon dietary or supplemental vitamin C.
I know, I know. I can hear you saying: “I never want to live that long.” But you might give this more consideration once you understand these animals lived most of their lives without growing old – no wrinkles, no hair loss, no cataracts, no heart attacks, no cancer, no brain plaque or decline in brain function (see the graphic below):
A second way to achieve lifespan/healthspan prolonging vitamin C blood levels is to consume vitamin C pills.
Public health authorities have only recommended 60-200 milligrams of dietary and supplemental vitamin C per day, a disparity of 10 to 60-fold over what the body is estimated to have once produced internally.[15]
Modern humans consume only ~110 milligrams of vitamin C per day from their diet. Biochemist Irwin stone estimated human internally produced 1800 to 4000 mg vitamin C in unstressed conditions.[16] Optimal blood levels can be achieved by repeated vitamin C throughout the day – 500 mg every 4-6 hours.[17] Vitamin C is rapidly excreted so repeat supplementation is required to maintain optimal blood levels.
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But vitamin C is widely available and can be used immediately without prescription. Place a bottle of vitamin C pills on your kitchen shelf, on your desk at work, in your car and at your bedside, and you will find it a lot easier to remember to take your vitamin C pills throughout the day.
It will cost health seekers more to NOT supplement their diet with vitamin C than it will to take vitamin C pills throughout the day to mimic natural secretion.
Taking vitamin C throughout the day will not responsively increase C levels with increasing mental or physical stress, as does restoration of the GULO gene. You need more vitamin C under biological stress but there is no way to determine how much.
The fact that this monumental discovery is being read here and not in prestigious medical journals like The New England Journal of Medicine, or The Journal of the American Medical Association, nor from major news sources, speaks legions.
Modern medicine is not ready to have a trillion dollars of medical billings taken away. And life insurance companies profiteer off their clients dying on time. There are a lot of things that restoration of vitamin C synthesis would change if the public learns of this and takes action.
The unwelcome mat has been out for a long time regarding the GULO gene and its infamously absent enzyme that converts blood sugar to vitamin C. In lieu of small molecules to restore GULO gene activity, the consumption of 500 mg. of vitamin C every 4-6 waking hours is a viable alternative.
Modern medicine is overpriced, beyond affordability for most Americans. Some people have to mortgage their homes for life saving treatment. About 30 hospitals a year are folding. A shortage of 42,600 to 121,300 physicians is predicted by the year 2030. The relief valve for what ails the healthcare system is vitamin C.
Sadly, at any time in the last 60 years this gene mutation could have been compensated for with repeated use of vitamin C pills throughout the day. However, public health authorities led consumers away from vitamin C pills. This vitamin will work like no other pill by dramatically reducing demand for healthcare. It’s a pill modern medicine refuses to swallow. Adoption of vitamin C supplementation throughout the day or consumption of a gene modifying natural molecule by the public would spare Medicare from predicted insolvency and avert needless suffering and grief for countless millions of people.
References
[1] Beyond Vaccines: End Of The Vaccine Era, Bill Sardi, www.beyondvaccines.com
[2] Rath, Matthias, Why Animals Don’t Get Heart Attacks but People Do, 1997. https://www.amazon.com/Animals-Dont-Heart-Attacks-People/dp/0963876856
[3] Stone, I., (1972) The Natural History of Ascorbic Acid in the Evolution of the Mammals and Primates and Its Significance for Present Day Man. Orthomolecular Psychiatry, 1, 82-89.
[4] Andersson, M., Walker, A.R., Falcke, H.C. (1956) An investigation of the rarity of infantile scurvy among the South African Bantu. British Journal Nutrition, 10(2), 101-05.
[5] Odumosu, A., Wilson, C.W., (1971) Metabolic availability of ascorbic acid in female guinea-pigs. British Journal Pharmacology, 42(4), 637P-38P.
[6] Cummings, M., (1981) Can some people synthesize ascorbic acid? American Journal Clinical Nutrition, 34(2), 297-98.
[7] Toyohara, H., Nakata, T., Touhata, K., Hashimoto, H., Kinoshita, M., Sakaguchi, M., Nishikimi, M., Yagi, K., Wakamatsu, Y., Ozato, K. (1996), Transgenic expression of L-gulono-gamma-lactone oxidase in medaka (Oryzias latipes), a teleost fish that lacks this enzyme necessary for L-ascorbic acid biosynthesis. Biochemical Biophysical Research Communications, 223, 650-53.
[8] Genscript. Gulo CRISPR guide RNA, gulonolactone (L-) oxidase CRISPR guide RNA (house mouse). https://www.genscript.com/gRNA-detail/mouse/268756/Cas9/Gulo-CRISPR-guide-RNA.html, accessed 8/17/2018.
[9] Chen, K., Blewitt, M.E., (2017) How do mutations in epigenetic regulators contribute to disease? Epigenetics, Oct. 2017.
[10] Franco, S.S., De Falco, L, Ghaffari, S., Brugnara, C., Sinclair, D.A., Matte’, A., Iolascon, A., Mohandas, N., Bertoldi, M., An, X., Siciilano, A., Rimmelé, Cappelini, M.D., Michan, S., Zoratti, E., Anne, J., De Franceschi, L., (2014) Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice. Haematologica, 99(2), 267-75.
[11] Chowdhury, A.R., De, P., Chakravarty, S., Chakravarty, A., (2017) Resveratrol as an alternative to regular blood transfusion – a new fetal haemoglobin inducer from natural world. International Journal of Advanced Research, 5(1), 1816-21.
[12] Stone, Irwin, Homo Sapiens Ascorbicus, A biochemically corrected robust human mutant. Medical Hypotheses, Volume 5, pp. 711-22, 1979.
[13] Aumailley, L, Warren, A., Garand, C., Dubois, M.J., Paquet, E.R., Le Couteur, D.G., Marette, A., Cogger, V.C., Lebel, M., (2016) Vitamin C Modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo -/- mice. Aging, 8(3), 2016.
[14] Aumailley L, et al, Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo-/- mice. Aging, Volume 8, No. 3, pp 458-83, 2016.
[15] Levine, M., Conry-Cantilena, Wang, Y., et al. (1996) Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proceedings National Academy Science, 93, 3704-09.
[16] Stone, I., (1966) Hypoascorbemia, the genetic disease causing the human requirement for exogenous ascorbic acid. Perspectives Biology Medicine, 10(1), 133-34.
[17] Hickey, D.S., Roberts, H.J., Cathcart, R.F. (2005) Dynamic flow: a new model for ascorbate. Journal of Orthomolecular Medicine, 20, 237-44.
