The horrific assassination of Benazir Bhutto is a massive blow to the empire, since she was the handpicked US replacement for the hated Pervez Musharraf. The US had installed Musharraf as military dictator after kicking out his elected predecessor, Nawaz Sharif (ah yes, global democracy), who was considered insufficiently obedient. The US has spent many billions on Musharraf and his military, but it has only earned the contempt of Pakistanis who don't like being a US colony (and no, one does not have to be pro-terrorist to be opposed to foreign control). What will happen now in Pakistan? Nothing good. At the same time, the US occupations of Iraq and Afghanistan continue to go badly, and Turkey--with US support--is bombing the Kurds in Iraq, the most pro-American part of the population. All over the world, other occupied areas grow restive as well.
Meanwhile, thanks to the Fed, the dollar weakens every day, risking a key pillar of US hegemony. Domestically, housing heads into a 1930s-style crisis, with more of the economy to follow.
This is the way empires end: in blood and economic disaster. The regime will want to do more of the same: inflate and bailout at home, threaten and bomb abroad, which will only worsen everything.
There is only way out: cut spending, cut taxes, stop inflating, end the police state, bring the troops home. Peace and freedom: libertarianism, in other words. How blessed we are, at the very moment of crisis, to have Ron Paul.
UPDATE Needless to say, only Ron Paul among the candidates has opposed US intervention in Pakistan, and the massive foreign aid to its government.