Could We One Day Get Our Daily Dose of Exercise From a PILL? Scientists Design Compound That Mimics Exercise in Muscles

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Scientists believe we could be closer to developing a drug that gives us the benefits of exercising without moving a muscle.

A studies has shown that a compound affected levels of a protein called REV-ERB in muscles – which has been shown to boost metabolism, normalise cholesterol levels and affect how much we sleep.

Experts hope that the compound could one day help disabled people get the benefits of exercise without having to move.

The study, published this week by researchers at the Scripps Research Institute in Florida, found that when their compound was injected into obese mice, it helped them lose weight - even if they were on a high-fat diet – and improved their cholesterol levels, according to a New York Times report.

The treated mice also began using more oxygen throughout the day and expending about 5 per cent more energy than untreated mice, even though they were not moving about more than the other animals. 

This in effect means the compound boosted their metabolism.

Scripps scientists also worked with researchers at the Pasteur Institute in France and other institutions, to discover what their compound might be doing inside muscles to provide this ‘invisible’ exercise. 

They knew that their drug increased the potency of the REV-ERB protein, but no one knew what it actually did to muscles. 

They therefore developed a strain of mice that could not express very much of the protein in their muscle cells.

These animals were what they described as ‘anti-athletes’. 

One of the hallmarks of regular aerobic exercise is that it increases the number and activity of the mitochondria, the cellular structures that help to generate energy while consuming oxygen, in the muscles.

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